The Governor calls on Team Scorpion when his daughter is mysteriously "bio-hacked" with a deadly virus and has only 24 hours to live. Meanwhile, the case takes on a deeper significance for Walter after he receives a letter regarding his sister.
The BAU investigates an urban vampire in New York who kidnaps his victims at night and holds them underground in the sewer system. Also, Reid makes an impossible decision in prison that severely affects himself and other inmates.
Mickey tries to quit smoking. Meanwhile, Ben meets a new friend.
When a recruit officer at the NYPD Academy is killed, Beckett and the team go back to their old training ground to investigate. Meanwhile, Castle must reckon with a decision with profound consequences for him and Beckett.
Max joins Caroline on a trip to visit her father in prison. Recurring guest star JENNIFER COOLIDGE appears as Sophie, the girls’ upstairs neighbor.