Sherlock is called in to investigate when a supposedly uncrackable bank vault called "The Leviathan" is breached. Meanwhile, Joan is pleasantly surprised when Sherlock meets her family and defends her choice to become a sober companion.
In the aftermath of tragedy, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike Delfino's real reason for moving to the street, Lynette reaches the breaking point in her addiction to the twins' ADD medication, and the mysterious Mr. Shaw (guest star Richard Roundtree) gets down to business.
A series of freeway car accidents leads to a catastrophic overpass collapse that endangers the lives of civilians and members of the 118.
House returns home to Princeton where he continues to focus on his recovery. At the suggestion of Dr. Nolan, he steps down from his post as Head of Diagnostic Medicine because he attributes his unhappiness and subsequent addiction to the hospital. The team needs him more than ever when they are unable to diagnose a loud-mouthed video game creator who posts each new symptom on the internet and opts for treatments suggested by the online community rather than by the doctors. Meanwhile, as Foreman angles for House's old job, the pressure to solve the case creates tension in his relationship with Thirteen.
Look back at how Chimney joined Station 118 and became the firefighter and paramedic he is today.
