To regain key incriminating information about his father's past that he lost when his memory was erased, Lex joins an experimental program headed by Dr. Garner (recurring guest star Martin Cummins). Knowing that Lex will also remember the secret of Clark's powers if he regains his memory, Clark tries to stop him--but Lionel and Garner capture Clark and expose him to the same radical treatment, hoping to reveal his mystery.
The Commonwealth vessel Andromeda, captained by Dylan Hunt, responds to an urgent distress call to find itself lured into a trap.
A signal from the past brings Dylan and his true love, Sara, back together.
The secret of the asteroid becomes public following a nuclear incident, setting the world on a dangerous course. Also, Darius, Grace, Liam and Harris must adapt to new roles in an ever-shifting landscape of fear and civil unrest.