While Mary’s away, George finds himself giving advice on Missy’s love life. Meanwhile, Sheldon and Dr. Linkletter struggle to solve an equation; and Georgie has a solution for Meemaw’s business woes.
When Daphne sends a troubling text message to Lily, Marshall enlists the gang’s help to remove the message while enforcing the “No Questions Asked” rule.
The Jeffersonian team investigates the murder of a food scientist whose remains were tossed in a meat grinder and mixed into cans of stew served in a school cafeteria. When the team uncovers the scientist’s newest – and highly lucrative – food invention, they begin to track the trail of jealous competitors in the multi-million dollar food industry. Meanwhile, Angela plans a post-wedding bachelorette party for Brennan and it gets crazier than intended.
In the season five premiere, Dexter reels from Rita's murder and makes a choice that will affect everyone's lives. Quinn stirs up trouble by suggesting that Rita's death doesn't fit Trinity's profile.
The family travels to Las Vegas when Hal experiences a dream about hitting the jackpot; Dewey and Reese enter an enormously obese rabbit in a contest; Lois gets to meet her favorite singer backstage; Otto and Francis get trapped in a well.