As a Native American mystic attempts to heal Mulder, Scully pursues secret files on alien experimentation and unwittingly becomes a killer's target.
While trying to expose a government plan to create an alien/human hybrid, Mulder gains startling new information about his sister's abduction.
Mulder finds himself trapped on a speeding train with a government assassin, a ticking time bomb and a deadly virus.
To save his dying mother, Mulder must protect the extraterrestrial healer, Jeremiah Smith, from a ruthless alien bounty hunter.
Scully learns new details about her sister's murder as Mulder pursues the shapeless alien entity inside Krycek's body.