The investigation turns to the family as the BAU and local authorities race against time to locate a young girl who has disappeared from a shopping mall in Potomac Mills, Virginia.
Jane enlists his colleagues in a dangerous sting operation to catch a deadly team of art thieves. Meanwhile, sparks fly between Lisbon and an agent from the FBI's art squad – Marcus Pike (guest star Pedro Pascal).
Lightman and Torres interrogate an imprisoned gang leader who claims to be rehabilitated. If the gang leader is freed, he might help fight inner-city violence or return to his life of crime. Foster and Loker investigate the death of a firefighter who was killed in the line of duty.
Residency Director Dr. Leanne Rorish (Marcia Gay Harden) puts her four new first year residents to work immediately on their first day at Angels Memorial Hospital, in the busiest, most notorious hospital ER in the nation.