When a guilt-ridden Barney breaks the "Bro Code", he struggles with the ramifications of his misstep.
Izzie's mother arrives at Seattle Grace; Meredith and Lexie receive a visit from their apologetic father; Meredith and the Chief argue about a case.
When a fire breaks out in Stella's apartment, the CSIs investigate and determine it was arson.
In an attempt to get over his pain and move on, Owen employs Nick to learn the details of his wife's affair with his best friend, Ikey. Meanwhile, Eddie harbors a secret that could kill a business venture he plans with Nick.
Nick and Eddie head to New York in an attempt to bring Owen back to his estranged wife and family in Knightsridge, and Hannah comes to terms with her true feelings for Nick.