The doctors of County General Hospital in Chicago experience a difficult 24 hours in the series permiere.
Carter makes a serious error on his first unsupervised surgery. Dr. Ross treats a 4 year old AIDS patient whose condition was made worse by the wrong medication.
Benton cares for a patient who has been abused by her police officer husband and Lewis decides to keep Suzie.
Carol is suffering because she has to fire two of the nurses. At that night, the girl whom Dr.Ross care about arrives ER by raping incident. Dr. Carter spends the last night with Abby at her office.
A demented patient causes a shootout in the emergency room. After terrorizing people in the ER with a gun, she gets shot by a policeman. She soon dies. Benton later discover her dementia was caused by an aftereffect of his surgery that he and Cleo should have detected. Carter pursues a cute intern. After a particularly long surgery, Corday decides to take her maternity leave. And April Fool's pranks abound in the ER.