Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to take the case so emphatically, House forces Cameron to take the lead and run many of the tests on the patient. Meanwhile, House is unsure of Wilson’s new healthy diet.
The doctors try to cope with heartache and injuries caused by the plane crash; everyone at Seattle Grace struggles to return to normalcy amid the chaos.
After helping Carlos conceal his crime, guilt weighs heavily on Susan, Gaby, Bree and Lynette; Tom and Lynette's marriage continues to disintegrate; Renee pursues a sexy new neighbor.
As an irascible federal judge (guest star Stephen Root) hears a controversial coal company case, an FBI investigation complicates Raylan’s (Timothy Olyphant) efforts to replace the money Winona (Natalie Zea) took from an evidence locker. And as Raylan and Winona struggle to put the money back before its disappearance is discovered, a coal company executive hires Boyd Crowder (Walton Goggins) for her security team.
Dexter and the Homicide Division race against a lunar eclipse to catch the Doomsday Killers before their final gruesome act. Debra struggles with, but finally faces up to, a new emotional reality.