MacGyver and Frank Colton join forces to track down a Bulgarian defector who was the accidental witness at a murder and is unwittingly in possession of a map to a valuable gem the killer seeks to obtain.
loki faces a paternity suit and jail when a teen fingers him as the father of her child.
Mentally challenged Howie (Neil Patrick Harris) is the last unaffected person in a small town overrun by a parasitically-induced madness. Howie is desperate to save his sister Sheila (Christine Hirt), but deprived of her guidance for the first time, he must rely on his own strength to overcome the madness.
After Mitchell Huston dies under mysterious circumstances at the Green Abbey hospice, Father Geddes points the finger at Dr. Sarah MacInnis. MacInnis ends up arrested, and Maz tells Ali he thinks they have an open and shut case.
One of Tony's men, Danny Nolan, goes ballistic when Joe Lund, the gun-wielding ex-husband of the woman Dan has been seeing, takes her hostage.
