Jess invites Paul (guest star Justin Long), a music teacher at her school on whom she always has had a crush, to the gang’s big Thanksgiving dinner at the loft, which naturally goes horribly awry.
Two young engaged scientists die in a fire and a mentally challenged neighbor Charlie Headlind (Guest Star Christian Anderson) is badly burned trying to save the couple. Detectives Cyrus Lupo (Jeremy Sisto) and Kevin Bernard (Anthony Anderson) discover that both of the victims were stabbed before they burned in the fire, leading them to a mentally disturbed woman, Wendy Teal (Guest Star Gretchen Hall), Charlie's former girl. Also stars S. Epatha Merkerson, Sam Waterston, Linus Roache and Alana de la Garza.
Cheryl and Dana are forced to smash their way out of a locked garage because they ignored Jim's lesson on how to open the door from the inside.
Billie tries to live vicariously through Zack and Davis by offering them dating advice. However, things take a turn, when the objects of the boys' affection reveal their true intentions.
Secret agent James T. West poses as a notorious desperado, Frank Slade, inaplan to arrest a Mexican bandit, Colonel Vasquez, who has been robbing banks in American border towns and then fleeing to the sanctuary of Mexico.
