Chris O'Donnell

The doctors of Seattle Grace help Izzie cope with the loss of her fiancé, Denny, and her decision to quit the internship program. Meredith must decide what the future holds after her hospital liaison with Derek. The Chief is confronted by his wife, Adele, after spending the night in his office, and George seeks relationship advice from a surprising source, on the season premiere of "Grey's Anatomy."

Addison doubts her abilities as a doctor, Cristina pushes Burke's rehabilitation, one of the interns suffers their own medical emergency, and Izzie receives the surprise of her life.

Cristina tries to help Preston cope with his hand tremor, Izzie attempts to return to the hospital for the first time since she quit the program, Alex deals with a patient who has a long history of injuries, and George and Callie's relationship moves forward.

Cristina meets Burke's parents -- and in the most awkward of circumstances -- the interns campaign for Izzie's reinstatement to the surgical intern program, Addison takes a break from her hospital duties, and a surgical patient lives what may be her last day to the fullest.

Izzie grills George about the personal details of his life, Addison takes Alex to task about a sensitive case, and Burke feels the pressure when he treats his musical hero.