A case involving a serial killer believed to be copying Jack the Ripper takes Gideon to New Orleans after three victims are found with their throats cut.
Jane and the CBI try to find the killer of a young man found burned to death outside a cabaret featuring female impersonators.
Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns
The new interns are dazzled by the skill level of fellow intern George, while Lexie helps keep his "repeater" status a secret; Meredith half-heartedly helps Lexie with her first emergency patient.
The hospital has a pipe break which causes a huge flood; Meredith quits therapy but Dr. Wyatt doesn't believe she is finished.