A case involving a serial killer believed to be copying Jack the Ripper takes Gideon to New Orleans after three victims are found with their throats cut.
Cristina, back from her honeymoon trip, searches in vain for Burke; Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns
The residents and interns treat the victims of a massive explosion at an apartment building, while Alex investigates the cause of the accident.
The new interns are dazzled by the skill level of fellow intern George, while Lexie helps keep his "repeater" status a secret; Meredith half-heartedly helps Lexie with her first emergency patient.
Cristina and Burke's wedding day arrives - along with the interns' first exam results - and a successor to the Chief is named, as Callie and George make a big decision about their relationship.
