Frankie has to force Brick into asking Cindy to the high school prom, but worries that his quirkiness could spoil the happy event; Lexie talks a clueless Axl into giving Sue a belated 21st birthday present; and Mike becomes frustrated over how to get used to a new TV remote.
Dr. Murphy becomes obsessed with performing an autopsy on a Jane Doe, which challenges his relationships at the hospital; a male college student has a mysterious split personality disorder.