After vanquishing a Manticore demon, Piper, Phoebe and Paige become foster parents to its orphaned half breed infant but upon Chris' plea to vanquish the child, they believe that by raising the child with love they can change its destiny.
On the heels of her and Tom’s (Michael Vartan) wedding, an attack in the hospital parking lot endangers both Christina (Jada Pinkett Smith) and her unborn child. And as Morrissey (James Morrison) looks to appoint a new head nurse, Steve (Adam Rayner) makes an important decision about his future.
As Christina (Jada Pinkett Smith) persuades Nick (Marc Anthony) to have a birthday party for his ailing mother, Camille’s relationship with Miles (Derek Luke) is endangered after her negligence nearly kills his son. Meanwhile, Gail (Vanessa Bell Calloway) confronts Morrissey (James Morrison) about his drinking.
When Neesee borrows Robert's assistant, Kenny, to help her around the house, a war starts between the exes, who divide their belongings and household duties.
As the Internal Affairs investigation into the death of Christina’s (Jada Pinkett Smith) attacker strains her relationship with Tom (Michael Vartan), Kelly (Vanessa Lengies) can’t get anyone to listen when she suspects that a dangerous infection is spreading through the hospital. Meanwhile, Camille (Hannah Hodson) plunges headlong into Miles’s (Derek Luke) messy personal life.
