Abruzzi, Sucre and C-Note make a run for it on their own; Michael and Lincoln plan another breakout – this time to rescue a jailed LJ, whom Mahone targets in his quest to capture the escaped cons; Bellick and Warden Pope face a jury of their peers regarding the prison escape; Tweener hitches a ride with the college crowd; and T-Bag takes drastic measures to get the upper hand.
T-Bag goes postal to track down a missing Mrs. Hollander. Sucre's escape plane faces deadly turbulence. Bellick has the tables turned on him upon his return to Fox River Penitentiary. Michael and Lincoln are taken into custody to be transported back to Fox River, forcing Mahone and Kellerman to take drastic measures to ensure that the brothers make it to the prison morgue instead of their cells. And a surprising ally changes the game for everyone.
McGarrett and Five-0 once again become entangled in the twisted mind games of serial killer Dr. Madison Gray (Elizabeth Röhm) when she stumbles into HPD covered in blood that matches Alicia Brown's (Claire Forlani), and claims amnesia.
After Walker captures a criminal known as "The Iceman," who had been wanted by the F.B.I., he realizes that his friend, ex-con Charlie Brooks is a dead-ringer for "The Iceman" and convinces Charlie to impersonate him in a dangerous plot to end the crime boss' reign of terror.
After receiving a serious head injury during a drug bust, Walker is under his doctor's orders to take a relaxing vacation, which turns out to be far from stress-free.
