With the absence of Captain Pruitt, Andy and Jack try to navigate how to work together, and a car accident on a rural road puts both the victims and the crew's lives at risk.
The doctors contend with a pandemic.
Ed and the crew set out to save Dr. Finn, her two sons and Isaac after their shuttle gets thrown into unchartered space and they crash-land on a moon that is light years from the Orville.
Kelly discovers that Lt. John Lamarr is smarter than he lets on. So, she pushes Ed to consider him for a key leadership position on the ship after The Orville gets damaged by a mysterious spatial anomaly causing harrowing effects to all things living.
The Orville is called to mediate a peace treaty between two warring cultures, but tensions run even higher between Ed and Kelly when a familiar face boards the ship. Meanwhile Yaphit declares his love for Dr. Finn with surprising results.