With the absence of Captain Pruitt, Andy and Jack try to navigate how to work together, and a car accident on a rural road puts both the victims and the crew's lives at risk.
The doctors contend with a pandemic.
Ed and the crew set out to save Dr. Finn, her two sons and Isaac after their shuttle gets thrown into unchartered space and they crash-land on a moon that is light years from the Orville.
The Orville is called to mediate a peace treaty between two warring cultures, but tensions run even higher between Ed and Kelly when a familiar face boards the ship. Meanwhile Yaphit declares his love for Dr. Finn with surprising results.
Kelly discovers that Lt. John Lamarr is smarter than he lets on. So, she pushes Ed to consider him for a key leadership position on the ship after The Orville gets damaged by a mysterious spatial anomaly causing harrowing effects to all things living.