Bess Armstrong

A scheming Frasier finally works his way into hosting the annual televised Christmas parade but he is horrified to learn that his wildly successful protege - the sassy, brassy radio host known as Dr. Mary will be his substitute co-host, prompting a battle royale for control of the microphone.

At the hospital bed where Dan lies after a heart attack, Deb contemplates her role in the tragedy. On his way to attempt reconciliation, Dan had found Deb making love to Keith. Meanwhile, Haley and Nathan have gotten married in a ceremony attended only by her parents. Peyton and Brooke begin to recapture their friendship with a day on Brooke's family boat and vow to avoid letting guys come between them again. Whitey learns that he has a brain tumor. And Lucas is living in Charleston with Keith, both having left their problems behind and started new lives. But the news of Dan's hospitalization leads to some soul searching on both of their parts, and when Lucas and Keith arrive back in Tree Hill, life onlybecomes more tumultuous for everyone involved.

With the assistance of Peyton and Brooke, Lucas gives Nathan and Haley a wedding reception. Although Haley's parents, Jim (Huey Lewis - "Duets") and Lydia (Bess Armstrong - "My So-Called Life"), support their daughter's marriage, Deb doesn't. Meanwhile, Dan's recent heart attack causes him to try mending his relationships with Deb and Lucas.

Frasier competes in a weight loss charity event.

The local authorities in Cleveland enlist the help of the BAU to assist in the pursuit of a serial killer who appears to be copying the methods used by famous murderers from the past.