Sheldon battles President Hagemeyer’s mysterious boss over the University’s science requirements. Meanwhile, Mary discovers that Georgie is working at Meemaw’s illegal gambling room.
The BAU search California's Angeles National Forest after a number of bodies mysteriously turn up in the mountain lakes there. Also, Rossi struggles with an agonizing decision regarding his ex-wife.
Derek, Meredith, Arizona and Cristina receive news about the plane crash lawsuit; Richard avoids Catherine's advances; Jackson takes on one of Mark Sloane's former patients.
Things don’t go as smoothly as planned for the Hecks when Frankie helps Sue celebrate her 21st birthday by taking her to a bar close to the college; Mike begrudgingly accompanies Brick to a “Planet Nowhere” convention; and Axl and Hutch head to Ohio in the Winnebago to attend and make a toast at ex-college roomie Kenny’s wedding.
Bree is exposed to a dangerous toxic and Adam and Chase search for an antidote.