Ben Reed

The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever.

The NCIS team is called in to investigate when a body dressed as a Navy lieutenant is discovered apparently raped and murdered.

Will (Eric McCormack) invites Jack (Sean Hayes) to his gym on a 'buddy pass,' but when he expresses his embarrassment to Grace (Debra Messing) over his buddy's gay behavior, Jack overhears the comments and looks to set him straight about prejudice. Meanwhile, Grace (Debra Messing) continues to lend her ear when Karen's (Megan Mullally) marriage hits rocky ground and she and Karen share an evening of girl talk.

Kyra feels she has no choice but to break up with her new boyfriend after Reba meets his divorced dad and the two adults start flirting with each other.

Catherine, Warrick and Nick find the body of two women at a construction site buried under tar.The swing shift are brought into the world of foreign "mail-order" brides.