Ayisha Issa

Cole gets stranded in 2016 after an attempt to destroy the virus changes the future; Jones and Railly deal with the consequences of the changed timeline.

In the present day, Cassie (Amanda Schull) and Jennifer Goines (Emily Hampshire) are on the run from the 12 Monkeys in a desperate attempt to unravel the next part of the conspiracy. Meanwhile, in 2044, Cole (Aaron Stanford) and Ramse’s (Kirk Acevedo) conflict with Deacon (Todd Stashwick) comes to a head.

After the tragic events of the meltdown, Jones is left with the disheartening realization that humanity’s true enemy is time-travel itself. As its architect, she elects to do the unthinkable - send Railly back in time to 2020, to kill Jones while she was still at Spearhead in order to undo all of it. However, Cole and Railly discover a shocking anomaly in their quest to carry out Jones’s wishes

With the temporal facility on the verge of destruction, Cole and Jones find themselves in the middle of a coup. After a violent encounter ends in an unexpected tragedy, Cole is sent back to 1957 in a last-ditch effort to save humanity while the rest embark on a caravan across the apocalypse to find Titan -- the stronghold of the Witness.

Cole and Railly have finally found peace living in the past. When a mysterious woman with apocalyptic visions of the future tells Cole it's not over, he must do the unthinkable to save the world... and the woman he loves.