An STD outbreak amongst Pawnee seniors prompts Leslie to conduct a sex education class. Meanwhile, Ron helps Tom adjust to life without technology after his gadgets are taken away, and Ben and April meet Congressman Murray for the first time.
Everyone's lives on Wisteria Lane are forever changed when Carolyn Bigsby holds shoppers hostage at a local supermarket. Meanwhile, Gabrielle and Carlos finish dividing their assets: Gabrielle gets the house, and Carlos gets everything in it. Susan is preparing to go to Paris with Ian.
A terrible storm causes a power outage, and the backup generators fail. The staff frantically works to keep patients alive. Carter tells Roxanne he doesn't want to have a relationship with her anymore. A 20-year-old comatose female patient from another floor is beaten, sexually assaulted and left at the emergency room.
A 60-year reunion of World War II female factory workers stirs up memories of a mysterious death. A friend of the deceased confides to Rush that the death is not what it appears to be and begs her to dig deeper into the case. After several interviews, Rush soon discovers that the women were not as innocent as they seemed in 1943.
Voodoo appears to be the only explanation when unmarked dolls sent to San Francisco residents accurately predict a series of inexplicable deaths -- including, perhaps, Natalie's. Meat Loaf guest stars.