Preston and Porter move out; Gaby and Carlos visit her hometown; Keith asks Bree to move with him to Florida; Susan uses her ailment to get special treatment; Paul makes a decision about Beth.
While Jane and the team examine a crime scene where a baseball scout has been found murdered, Jane is clocked in the head and knocked unconscious by a ball – causing him to flash back to his childhood with his overbearing father, Alex (guest star Nick Chinlund – Desperate Housewives).
Will and Grace find themselves “cheating”on their old, dull friends Rob and Ellen. Karen can no longer dodge the parent-teacher conference at her step kid’s school.
When a kiss between two gay men scheduled to air on TV doesn't happen, Will (Eric McCormack) and Jack (Sean Hayes) go to the network to complain and have an unexpected meeting with the "Today" show's Al Roker (gueststarring as himself). Debra Messing and Megan Mullally also star in this episode partially shot on the streets of New York City.
Frankie insists that the family go on vacation together before school starts; Mike and Frankie remember their honeymoon, which was ruined by Nicky (Ray Romano), a guy Mike knew in high school.