The Atlantis team encounters the Hoffans a human civilization in the process of rebuilding their society since the last attack of the Wraith. The resilient Hoffans have developed the beginnings of a drug that could potentially make them immune to their enemies. Fearing that the next Wraith culling will come before they are able to complete their tests the leaders demand that their people be inoculated before the drug can be proven safe. Dr. Beckett (Paul McGillion) argues that there is no way to know what the true effects of the drug will be. Can Beckett make the Hoffans see reason or has their haste made them blind to the epidemic they may be unleashing upon themselves?
As the Fringe team investigates a mentally ill patient who appears to be connected to a series of murders, frightening clues and connections are uncovered that lead Olivia to some shocking revelations.
After asking for a divorce from her controlling husband, a kind-hearted teacher and her new boyfriend are framed for drug possession.
The sliders find themselves in paradise parallel earth. But they must move on and this time they are in a disease-ravaged environment with no medicine to cure the Q virus. They are on an earth where antibiotics were never discovered, and a raging bacterial infection threatens to wipe out the population in this Sliders episode entitled "Fever".
Dr. Madison Butler (William Katt) is given The Dead Man's Gun as payment for delivering a child, and when he saves the life of an alleged outlaw, the local townspeople turn on him for saving a killer who would hang anyway.