While making amends with Kirsten and her husband, Charlie gets some bad news about his health; Sarah's new romance makes Bailey reconsider seeing Annie, and a new competitor threatens Griffin's business.
On their wedding day, Julia doubts Griffin's commitment, while Charlie and Nina grapple with his illnesses effect on their relationship; Bailey's bringing Annie and her daughter disrupts Julia's wedding.
Charlie and his family struggle to come to grips with his cancer.
As Charlie's radiation therapy begins, he's reluctant to accept any help from his family; Bailey is rebuffed in his efforts to help Annie find a new job; and Julia looks for a job to help make ends meet.
As Bailey's relationship with Annie is tested by her daughter's reaction, Griffin and Julia struggle to keep their own marriage from falling apart in the face of the family's crises.