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Monica and Chandler's wedding reception is almost upstaged by the news that Rachel is pregnant. Elsewhere at the party, Ross tries to impress a pretty single woman; Chandler has trouble on the dance floor; and Joey hopes to impress an important Broadway producer who is dating Chandler's mother.

Addison invites co-workers to her house for a get-together, but no one RSVPs; Violet gets upset when her ex-boyfriend's wife visits the wellness center for medical treatment; Cooper counsels a young patient who is lovesick; Sam appears on his first talk show promoting his self-help book.

A woman who was pulled over by police is found murdered two miles up the road from the stop. It's not long before Robbins determines that the woman is, genetically speaking, not a woman.

Christine worries that she has lost her ability to attract men. When Richard's very attractive brother, Joe (Charles Esten - "The Office"), kisses her, she feels revitalized--but she finds out a surprising secret about Joe that even Richard doesn't know.

The CSI's offices have relocated to a Manhattan high rise which includes new labs, a staff break room and new office equipment with state of the art technology. Also, after expressing his interest in moving out of the coroner's office, Dr. Hawkes joins the team in the field and his first case has him working with Mac on the death of a skyscraper climber. Although hundreds of witnesses were on hand to see the climber fall, the team suspects foul play and believes someone caused his death. (TV-14)