Alison Ward

Cristina, Izzie and Meredith aggressively pursue the case of Shane, a male patient who seems to have a hysterical pregnancy, which fascinates them and the entire medical staff; and a sheltered young patient inspires Alex to better express his feelings for Izzie.

Nash and Joe meet Lyle who tells them the secret location the SIU barge has been towed to. Joe returns Lyle's chihuahua Ginger who has been held hostage in return for the info. A truck deliberately rams into a van containing three prisoners. Nash and Joe arrive at the accident scene, with Nash figuring out that a phony paramedic van has taken the three prisoners in a successful escape attempt. Nash, Joe, Harvey and Evan arrive at the empty and disconnected SIU. The Mayor has granted a one week reprieve pending the Police Commission hearing. If Nash and company catch the three escaped prisoners, the SIU will be saved. Head of MCD Reuben Banks daughter Gina's immunity deal is also dependent upon the return of one of the escaped prisoners - Gina's former boyfriend, Jimmy ""Shank"" Brasher. The other two escapees are Darnell Galloway and Elliot Wong. Gina is kidnapped by Brasher. Jake Cage of Fugitive Recovery is already on the case, beating Nash to interview Mr. Footman, owner of the stolen

Nash is out of action after Caitlin accidentally shoots him in the butt. Joe and Bettina do a joint investigation with FBI agents to bust a clever con-artist. Cassidy is stalked by a deranged college student.

Nash must stop a sniper shooting victims at random; Evan proposes to Cassidy, who after a serious traffic accident, is left fighting for her life.

Nash and Joe are on the trail of a renowned assassin who has come to San Francisco to kill FBI special agent David Katz. Lisa Bridges returns from Paris and announces she's engaged to marry a famous French chef named Henri, but there's a problem; Nash and Lisa's divorce was never finalized--they're still married. The new S.I.U. is introduced.