A series of targeted kidnappings near Memphis have the BAU searching for a commonality between the missing persons and a motive to lead to the UnSub. Meanwhile, Savannah vents her frustration to Morgan about the amount of traveling he does for his job.
When Detective Bailey’s sister, Jess (guest star ALISHA WAINWRIGHT), runs into trouble with the law, Bailey must decide how far she’s willing to go to protect her family. Meanwhile, with Trish away on a company retreat, Murtaugh is left to help Riana navigate boy problems, and Riggs deals with the fallout of a night of heavy drinking.
Jace is on the run with both the Clave and Luke's werewolf back on his trail. When he learns Alec is in mortal danger, Jace schemes with Izzy, Magnus and Clary to find a way to save him.
To help get answers to what Valentine may be planning, Isabelle and Clary are sent on a mission to visit the Iron Sisters. Once there, more truths are revealed than Izzy and Clary planned. On a mission of their own, Simon and Maia are determined to find Luke who is still missing after the demon attack at the Institute.
Luke's sister shows up at the Jade Wolf claiming innocence about the recent attack. But with Luke not trusting a word Cleo says, he finds himself at odds with Clary who sees an opportunity to get to Valentine. Meanwhile, Simon gets dating advice from a surprising source as Isabelle takes a dangerous path.
