Alexandra Lydon

The team takes on the case of a 16-year-old factory manager who fell ill when her lungs suddenly filled with fluid while at work. The teenager informs House and team that she is an emancipated minor living on her own and supporting herself, and has ever since her parents passed away. The team begins treatment for suspected heart problems, but when Kutner chooses to sympathize with the patient rather than follow House’s directions, he and the team find out the hard way that the girl may not be telling them the truth. Meanwhile, Foreman asks for House’s permission to work on a clinical trial and House rejects his proposal. In an effort to prove himself capable of working without House’s supervision, Foreman takes on his own pediatric case. But when the unexplained illness brings the child to the brink of death, Foreman is left questioning his ability to work free from House’s custody.

Susan is surprised, and not pleasantly so, when she finds out who Edie's new boyfriend is. Meanwhile Lynette goes back to work, leaving Tom at home in charge of the house, which turns out to be a better plan in theory. Bree's mother-in-law, Phyllis (guest star Shirley Knight), continues to drive Bree crazy with her melodramatic grieving, and Carlos makes an unusual request of Gabrielle.

When Ducky and Abby confirm that they have identified the remains of at least five people, the NCIS team immediately begins notifying the families in the hopes of making some connection between the seemingly random selection of victims.

Archer sleeps with Charlotte and rather than facing Naomi, he flies to New York and leaves Addison to pick up the pieces; Naomi and Addison have a newborn patient that is born a hermaphrodite and the parents can't decide what course of action to take; Violet leads a couples' therapy group with Sheldon that illuminates their issues.

Archer visits Shran's icy homeworld to find an Andorian subspecies called the Aenar, to determine their connection to the marauder destroying ships in the region.