Al Coronel

George gets haunted and taunted by his ancestors on Día de Los Muertos. A maturing Chance refuses to participate in a family Halloween costume.

The team takes on the case of a 16-year-old factory manager who fell ill when her lungs suddenly filled with fluid while at work. The teenager informs House and team that she is an emancipated minor living on her own and supporting herself, and has ever since her parents passed away. The team begins treatment for suspected heart problems, but when Kutner chooses to sympathize with the patient rather than follow House’s directions, he and the team find out the hard way that the girl may not be telling them the truth. Meanwhile, Foreman asks for House’s permission to work on a clinical trial and House rejects his proposal. In an effort to prove himself capable of working without House’s supervision, Foreman takes on his own pediatric case. But when the unexplained illness brings the child to the brink of death, Foreman is left questioning his ability to work free from House’s custody.

A series of abductions and murders in Seattle send the BAU seeking an UnSub who was abused in the past and is out for revenge. Meanwhile, Garcia heads to Texas to confront the man she shot while defending Reid and herself, as he waits on Death Row.

Trashy neighbor Rita Glossner (recurring guest star BROOKE SHIELDS) talks an apprehensive Frankie into taking a road trip to an unknown destination; Mike takes an embarrassing fall at the quarry and has to deal with even more embarrassment when OSHA is called in to investigate; and Sue attempts to convince Axl to end his estrangement with the family after learning their true feelings about April.

The team's Thanksgiving plans are put on hold while they track an elusive international arms dealer in D.C. who recently murdered an MI6 officer who was Sloane's close friend.