A 16-year-old female Hurricane Katrina victim suffering from hallucinations about the tragedy is brought to House by his ex-bandmate Crandall (guest star D.B. Sweeney), who tells House he recently found out she’s his daughter. House takes the case despite feeling more pain than usual in his leg. He wants to run a paternity test to make sure his friend is not being scammed, but Crandall refuses.
Cristina and Burke's wedding day arrives - along with the interns' first exam results - and a successor to the Chief is named, as Callie and George make a big decision about their relationship.
The interns take their first-year medical exams; the residents attend to three injured mountain-climbers; Callie's suspicions of George and Izzie grow; Cristina struggles to write her wedding vows.
As the BAU wraps up an investigation into unusual stabbings in Upstate New York, Morgan's visit with one of the crime's survivors could uncover more questions left for the team to answer. Guest stars include Aasha Davis and Emayatzy E. Corinealdi.
After discovering the body of a man involved with creating artificial intelligence bots, the team must figure out whether the victim’s own A.I. bot was programmed to kill him. In the meantime, Bones plans a special surprise for everyone for her 40th birthday.