When Bill (Denis Leary) wakes up in the psychiatric wing at Sumer Hospital, he has trouble distinguishing his dreams from reality. He is quite certain of his sanity, but memories of being cryogenically frozen, tissue regeneration experiments and talk of a final lethal injection race through his mind. With the help of Ann (Hope Davis), the psychiatrist assigned to his case, he struggles to piece his memories together, while newer, more "rational" memories flood his mind. Struggling with his paranoia, Bill begins to question Ann's motives. Can he trust the only person in the position to help him or will she be the one holding the needle that does him in?
